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Published on: March 17, 2023
Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons
A W Smith1, O K Rønnekleiv2, M J Kelly2
1Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA.
Abstract:
Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
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