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In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings:

P A Porter1, I Osiecka, R T Borchardt

  • 1Merck Sharp and Dohme Research Laboratories, INTERx Research Corporation, 2201 W. 21st, Lawrence, Kansas, 66046.

Pharmaceutical Research
|November 26, 2013
PubMed
Summary

Everted intestinal rings proved superior to isolated mucosal cells as an in vitro model for predicting intestinal drug absorption. This model showed better correlation with in vivo bioavailability for drugs like theophylline and salicylate.

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