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Updated: May 5, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
Antibody suppression by zinc and nickel
1Department of Biology, University of San Francisco, 94117, San Francisco, CA.
Abstract:
Rats were treated with zinc chloride and with nickel acetate 2 weeks prior to immunization withE. coli bacteriophageT-1; antibody titers to bacteriophageT-1 were reduced 500-2600-fold in metal-treated rats compared to titers found in untreated control animals. Examination of the effect of metal treatment on lymphocyte blastogenesis revealed a significant reduction in the number of blast cells in the spleens of metal-treated rats.
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