Related Experiment Video
Updated: May 5, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Premature birth and its later effects: Towards preventive intervention
1Saint Louis University, USA.
Insights
Premature birth significantly increases risks for developmental disorders and other serious infant conditions. Early identification and intervention are crucial for preventing negative outcomes in high-risk infants.
Area of Science:
- Neonatal research
- Developmental pediatrics
- Public health
Background:
- Premature birth is linked to increased risks of cognitive-developmental disorders.
- Infants born prematurely face higher rates of failure-to-thrive, child abuse, and sudden infant death syndrome (SIDS).
- Premature birth acts as an early indicator of potential future health and developmental challenges.
Purpose of the Study:
- To review and summarize research on the associations between premature birth and adverse outcomes.
- To discuss two primary types of preventive interventions: managing sequelae and preventing prematurity itself.
- To establish parameters for future intervention efforts based on existing data.
Main Methods:
- Comprehensive literature review of studies linking prematurity to developmental issues and adverse infant outcomes.
- Analysis of existing intervention programs focused on preventing complications of prematurity and preventing premature birth.
- Synthesis of findings to propose guidelines for future interventions.
Main Results:
- A strong correlation exists between premature birth and subsequent developmental disorders and other adverse outcomes.
- Intervention programs targeting both the prevention of premature birth and the management of its consequences show varying degrees of success.
- Evidence supports the role of premature birth as a critical risk marker.
Conclusions:
- Premature birth necessitates vigilant monitoring and proactive interventions.
- Developing targeted strategies for both prevention and management is essential for improving long-term outcomes.
- Further research and refined intervention parameters are needed to mitigate the risks associated with prematurity.
Abstract:
Premature birth is associated with a substantially increased incidence of cognitive-developmental disorders as well as elevated rates of failure-to-thrive syndrome, child abuse, and sudden infant death syndrome. The research supportive of these relationships is reviewed and summarized. This data base strongly suggests that premature birth serves as an early "red flag" which signals risk for later dysfunction. Two types of preventive intervention are discussed: a) prevention of the sequelae of premature birth and b) prevention of premature birth itself. Intervention programs of both types which have been conducted are reviewed. The results of these programs, together with the data base on prematurity, are used as the basis for a set of parameters to guide future intervention efforts.
Related Concept Videos
Preventive Healthcare Services
Levels of Health Promotion and Illness Prevention
In primary prevention, actions taken before disease onset prevent the disease from...
Development of the Oral Microbiota
Teratogenicity
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Regression Toward the Mean

