Related Experiment Video
Updated: May 5, 2026

Model of Ischemia and Reperfusion Injury in Rabbits
Published on: November 3, 2023
The pharmacokinetics of amrinone at three dose levels in the rabbit
G E Larijani1, M L Rocci, D L Newman
1Division of Clinical Pharmacology, Jefferson Medical College and Department of Pharmacy, Philadelphia College of Pharmacy and Science, Philadelphia, PA.
Abstract:
Amrinone is a positive inotropic and vasodilatory compound being used to improve cardiocirculatory function in chronic cardiac failure. The linearity of the pharmacokinetics of amrinone was examined in New Zealand white rabbits given i.v. bolus doses of 1.5, 3.0, and 7.5 mg/kg amrinone. Blood samples were obtained serially for a period of 6 hours following amrinone administration. Serum concentration-time data were analyzed by nonlinear least squares regression, as well as non-compartmental techniques. There were no differences as a function of dose in the systemic clearance, elimination half-life, mean residence time, or average concentration of amrinone. The pharmacokinetics of amrinone appear to be linear in rabbits. The rabbit may be useful as an animal model to study various aspects of amrinone pharmacokinetics.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

