Conflict and error processing in an extended cingulo-opercular and cerebellar network in schizophrenia.
Karla E Becerril1, Deanna M Barch
1Neuroscience Program, Washington University in St Louis, USA.
Neuroimage. Clinical
|November 26, 2013
Summary
Individuals with schizophrenia show intact behavioral adjustments and brain activity related to errors and conflict. However, difficulties in representing task information may underlie cognitive deficits in schizophrenia.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Cognitive control deficits are a hallmark of schizophrenia, impacting behavior monitoring and response adjustment.
- Impaired adaptive control in schizophrenia affects responses to errors and conflict, crucial for goal-directed behavior.
Purpose of the Study:
- To investigate behavioral adjustments and brain activity in response to errors and conflict in schizophrenia.
- To clarify the role of brain regions involved in adaptive cognitive control and understand schizophrenia-related cognitive deficits.
Main Methods:
- A change-signal task was used to examine behavioral adjustments after errors and conflict.
- Brain activity was measured in individuals with schizophrenia (n=38) and healthy controls, focusing on error and conflict processing regions.
Main Results:
- Behavioral adjustments to errors and conflict were largely intact in individuals with schizophrenia.
- Intact neural responses to errors were observed in the dorsal anterior cingulate cortex, anterior prefrontal cortex, insula, and inferior parietal lobule.
- Conflict processing showed intact effects in the dorsal anterior cingulate cortex, anterior prefrontal cortex, insula, inferior parietal lobule, and thalamus.
Conclusions:
- Error and conflict detection systems appear functional in schizophrenia when task-relevant information is explicitly provided.
- Compromised representation of task-relevant information may contribute to observed alterations in error and conflict processing in schizophrenia.
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