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Influence of fibrinolysis activation on leukocyte adhesiveness. Preliminary report
In patients with thrombophlebitis receiving intravenously a nicotinic acid derivative, pentoxifylline and streptokinase the fibrinolytic activity and leukocyte adhesiveness were studied. The euglobulin lysis time was significantly shortened in all cases; at the same time the adhesiveness of leukocytes and the leukocyte number were reduced. The addition of the drugs to blood in vitro resulted in a significant increase in leukocyte adhesiveness; the fibrinolytic activity was enhanced only upon streptokinase. Leukocytes are believed to promote the thrombolytic effect of fibrinolytic agents.
In patients with thrombophlebitis receiving intravenously a nicotinic acid derivative, pentoxifylline and streptokinase the fibrinolytic activity and leukocyte adhesiveness were studied. The euglobulin lysis time was significantly shortened in all cases; at the same time the adhesiveness of leukocytes and the leukocyte number were reduced. The addition of the drugs to blood in vitro resulted in a significant increase in leukocyte adhesiveness; the fibrinolytic activity was enhanced only upon streptokinase. Leukocytes are believed to promote the thrombolytic effect of fibrinolytic agents.