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[Local streptokinase administration in massive pulmonary embolism]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1986
Summary
Local thrombolysis using streptokinase effectively treated acute massive pulmonary embolism. This pulmonary artery infusion rapidly improved patient outcomes and reduced pulmonary artery pressure in most cases.
Area of Science:
- Cardiology
- Pulmonology
- Thrombolytic Therapy
Background:
- Acute massive pulmonary embolism poses a significant mortality risk.
- Effective treatment strategies for pulmonary embolism are crucial.
Purpose of the Study:
- To evaluate the efficacy of local thrombolysis with streptokinase for acute massive pulmonary embolism.
Main Methods:
- Five patients with acute massive pulmonary embolism received streptokinase via pulmonary artery infusion.
- A loading dose of 250,000 IU was followed by 100,000 IU/hour maintenance dose.
- Treatment was monitored using hemodynamic and angiographic assessments.
Main Results:
- Four out of five patients showed clinical, hemodynamic, and angiographic improvements within 5-12 hours.
- Two patients with cardiogenic shock experienced significant recovery.
- One patient with recurrent embolism showed gradual improvement.
Conclusions:
- Local thrombolysis with streptokinase is a highly effective treatment for acute massive pulmonary embolism.
- Rapid improvement in clinical status and hemodynamic parameters was observed.
- Pulmonary artery infusion allows targeted delivery of thrombolytic agents.