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[Position and developmental trends in fibrinolytic therapy]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1986
Summary
Advances in understanding fibrinolysis and plasminogen activator mechanisms enhance thrombolytic therapy. New generations of fibrinolytic agents promise improved treatment for clot dissolution and hypofibrinolytic states.
Area of Science:
- Biochemistry
- Pharmacology
Context:
- Fibrinolysis research has deepened understanding of plasminogen activator formation and release.
- This insight has improved thrombolytic therapies using agents like streptokinase and urokinase.
Purpose:
- To explore advancements in thrombolytic therapy based on improved understanding of fibrinolysis mechanisms.
- To highlight potential new therapeutic agents and strategies for enhancing clot dissolution.
Summary:
- Enhanced understanding of plasminogen activator mechanisms has led to more effective thrombolytic therapies.
- Future advances are anticipated with tissue-derived plasminogen activator, pro-urokinase, and acylated fibrinolytic enzymes.
- New activators targeting plasminogen activator biosynthesis and release are expected for hypofibrinolytic states.
Impact:
- Improved therapeutic efficacy of existing fibrinolytic agents.
- Development of novel fibrinolytic agents with enhanced properties like depot effect and inhibitor resistance.
- Potential for better treatment outcomes in patients with hypofibrinolytic conditions.