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Updated: May 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Emerging drugs for prostate cancer.
Paul H Chung1, Bishoy A Gayed, Gregory R Thoreson
1UT Southwestern Medical Center, Department of Urology , 5323 Harry Hines Blvd. J8130, Dallas, TX 75390 , USA.
New FDA-approved drugs offer hope for prostate cancer patients resistant to androgen deprivation therapy. Physicians must stay updated on these advancements to provide optimal care for castration-resistant prostate cancer (CRPC).
Area of Science:
- Oncology
- Urology
- Pharmacology
Background:
- Androgen deprivation therapy (ADT) is a primary treatment for advanced prostate cancer.
- Castration-resistant prostate cancer (CRPC) develops when patients no longer respond to ADT.
Purpose of the Study:
- To review emerging drugs and recent FDA approvals for CRPC treatment.
- To discuss the implications of new therapies for patient management.
Main Methods:
- A PubMed database search was conducted to identify relevant articles.
- The review focuses on new medications and drug classes for CRPC.
Main Results:
- Five new medications that improve survival in CRPC patients have been FDA-approved.
- Additional novel treatments are under investigation.
Conclusions:
- Recent FDA approvals and emerging treatments show promise for CRPC patients.
- Physicians face challenges in optimizing the sequencing and combination of new and existing therapies.
- Keeping abreast of new CRPC medications is crucial for appropriate patient counseling and treatment.
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