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Updated: May 5, 2026
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Safety evaluation of topical valproate application.
Sun Young Choi1, Song Yi Seop, Moo Yeol Hyun
1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
Toxicological Research
|November 27, 2013
Summary
Topical valproate (VPA) shows minimal skin irritation potential in human studies. This suggests VPA may be safe for topical application, potentially aiding in hair regrowth treatments.
Area of Science:
- Dermatology and Pharmacology
- Cosmetic Science
Background:
- Topical valproate (VPA) is being explored for hair regrowth.
- Limited safety data exists for topical VPA formulations.
Purpose of the Study:
- To assess the skin irritation potential of topical valproate (VPA) in humans.
- To evaluate the safety of VPA for topical dermatological applications.
Main Methods:
- In vitro cell viability tests on keratinocytes, fibroblasts, and mast cells.
- Clinical patch testing and skin irritation assessments using microneedle rollers for transdermal delivery.
Main Results:
- VPA demonstrated no toxicity to skin cells in vitro.
- Clinical tests showed no significant irritation; one transient erythema case resolved within hours.
- No erythema or edema observed at 24 hours post-application.
Conclusions:
- Topical valproate (VPA) exhibits minimal skin irritation potential.
- VPA is considered safe for topical application on human skin.
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