Cardiovascular risk in psoriasis: a population-based analysis with assessment of the framingham risk score

Area of Science:

• Cardiology
• Dermatology
• Epidemiology

Background:

• Psoriasis is associated with an increased risk of cardiovascular disease.
• Accurate cardiovascular risk assessment is crucial for managing patients with psoriasis.

Purpose of the Study:

• To evaluate the effectiveness of the Framingham risk score (FRS) in predicting 10-year cardiovascular risk in individuals with psoriasis.
• To compare predicted cardiovascular risk using FRS with observed cardiovascular events in a psoriasis cohort.

Main Methods:

• A population-based cohort study included 1197 adult psoriasis patients (30-79 years) without prior cardiovascular disease.
• Predicted 10-year cardiovascular risk was calculated using FRS and compared to observed cardiovascular events.
• Standardized incidence ratios (SIR) and confidence intervals (CI) were used for comparison.

Main Results:

• The median FRS was 6.0%, while the observed 10-year cardiovascular risk was 6.9% (SIR: 1.14; 95% CI: 0.92-1.42).
• No significant differences in risk prediction were found between genders or age groups (<60 and ≥60 years).
• The FRS demonstrated reasonable cardiovascular risk estimation in the studied psoriasis population.

Conclusions:

• The Framingham risk score appears to be a reliable tool for estimating cardiovascular risk in patients with psoriasis.
• No adjustments to the FRS are necessary for risk stratification in this population.
• These findings support the use of FRS in clinical practice for managing cardiovascular risk in psoriasis patients.