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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
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Strategies for improving mucosal drug delivery
Flavia Laffleur1, Andreas Bernkop-Schnürch
1Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Nanomedicine (London, England)
|November 28, 2013
Summary
This review explores strategies to enhance mucosal drug delivery by improving drug permeation through absorption membranes. It details essential functions for drug delivery systems to overcome barriers and achieve therapeutic effects.
Area of Science:
- Pharmacology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Mucosal drug administration relies on drug permeation through the mucosal layer and epithelial tissue.
- Effective drug delivery systems must overcome biological barriers to achieve therapeutic outcomes.
- Understanding these barriers is crucial for developing advanced mucosal drug delivery strategies.
Purpose of the Study:
- To provide a comprehensive understanding of mucosal drug delivery.
- To improve existing strategies and develop new systems for enhanced mucosal drug delivery.
- To focus on strategies that enhance membrane permeability for drug absorption.
Main Methods:
- Review of current literature on mucosal drug delivery systems.
- Analysis of essential functions for drug delivery systems (mucoadhesion, solubility, permeation enhancement, release control).
- Discussion of strategies to overcome absorption membrane barriers.
Main Results:
- Identified key properties required for effective mucosal drug delivery systems.
- Highlighted the importance of enhancing membrane permeability for drug absorption.
- Discussed the influence of drug delivery system design on drug permeation.
Conclusions:
- Optimizing drug delivery systems is critical for successful mucosal administration.
- Further development is needed to lower barriers in mucosal drug delivery.
- Advanced strategies focusing on membrane permeation are essential for therapeutic efficacy.
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