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Cationic lipid-based targeted nanocarriers for respiratory diseases in children: prospects and challenges

Shuangshuang Feng1, Chunju Zhang1, Wenchao Han1

  • 1Department of Pediatrics, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China.

Nanomedicine (London, England)
|August 13, 2026
PubMed

Insights

Cationic lipid-based nanocarriers show promise for treating pediatric respiratory diseases, overcoming limitations of traditional therapies. Further research is needed to address safety and scalability for clinical use.

Area of Science:

  • Nanotechnology
  • Pulmonary Medicine
  • Pediatric Respiratory Diseases

Background:

  • Pediatric respiratory diseases like pneumonia, asthma, TB, and CF are major global health concerns.
  • Traditional treatments for these conditions have significant limitations, including toxicity and poor lung targeting.
  • Nanotechnology offers potential solutions for improved drug delivery to the lungs.

Purpose of the Study:

  • To review cationic lipid-based nanocarriers (CLNCs) for targeted pulmonary drug delivery in pediatric respiratory diseases.
  • To discuss formulation strategies, therapeutic potential, safety, and translational challenges of CLNCs.
  • To highlight advances in intelligent drug carriers and inhalable nanomedicines for precision respiratory medicine.

Main Methods:

  • Review of current literature on CLNCs for pediatric respiratory diseases.
  • Analysis of different types of CLNCs, including SLNPs, cationic liposomes, LNPs, and NLCs.
  • Examination of formulation strategies and therapeutic applications.

Main Results:

  • CLNCs demonstrate potential as effective drug delivery systems for pediatric respiratory diseases.
  • Various CLNC formulations (SLNPs, liposomes, LNPs, NLCs) are being explored.
  • Advances in nanomedicine are enhancing precision respiratory treatments.

Conclusions:

  • CLNCs offer a promising approach to overcome limitations of conventional pediatric respiratory disease therapies.
  • Significant challenges remain, including immune activation, cationic lipid toxicity, lung barrier penetration, stability, and scalability.
  • Multidisciplinary research and pediatric-specific clinical trials are crucial for translating nanocarrier systems into safe and effective treatments.

Keywords:
Cationic lipidnanocarriersrespiratory diseasetargeted drug deliverytranslational challenges

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