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Updated: May 5, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Pharmacogenetics of the nuclear hormone receptors: the missing link between environment and drug effects?

Elena De Mattia1, Eva Dreussi, Erika Cecchin

  • 1Experimental & Clinical Pharmacology Unit, Centro di Riferimento Oncologico-National Cancer Institute, Via Franco Gallini, 2, 33081, Aviano, Italy.

Pharmacogenomics
|November 28, 2013
PubMed

Insights

Genetic variations in nuclear receptors (NRs) influence how cancer drugs work. Understanding NR genetics can improve personalized cancer medicine by integrating these markers with traditional ones.

Area of Science:

  • Pharmacogenetics
  • Oncology
  • Molecular Biology

Background:

  • Genetic variations in drug transporters and metabolic enzymes are key pharmacogenetic markers in personalized oncology.
  • These variations alone do not fully explain interindividual differences in drug response.
  • Nuclear receptors (NRs) regulate genes involved in drug metabolism and transport.

Purpose of the Study:

  • To review recent findings on nuclear receptor pharmacogenetics.
  • To explore how NR genetics can be integrated with traditional markers for personalized cancer therapy.

Main Methods:

  • Literature review of recent studies on nuclear receptor genetics and pharmacogenomics.
  • Analysis of the role of NRs in regulating genes affected by xenobiotics and chemotherapy.

Main Results:

  • Nuclear receptors (e.g., PXR, CAR, RXR, FXR, LXR, VDR, PPARs, HNF4A) play crucial roles in drug metabolism and transport.
  • Genetic variations in NRs can significantly impact the efficacy and toxicity of chemotherapeutics.
  • NR pharmacogenetics offers a novel layer of understanding for drug response variability.

Conclusions:

  • NR pharmacogenetics is a rapidly advancing field with significant potential in oncology.
  • Integrating NR genetic markers with established pharmacogenetic markers can enhance personalized cancer treatment strategies.
  • Further research into NR genetics is essential for optimizing chemotherapy regimens.

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