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Updated: May 5, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
[SIBLING proteins: molecular tools for tumor progression and angiogenesis]
Virginie Lamour1, Marie-Julie Nokin, Aurélie Henry
1Laboratoire de recherche sur les métastases, GIGA (groupe interdisciplinaire de génoprotéomique appliquée)-Cancer, Université de Liège, Building 23, Sart Tilman, 4000 Liège, Belgique.
Abstract:
The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis.
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