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Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
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The use of botanically derived agents for hyperpigmentation: a systematic review
Whitney A Fisk1, Oma Agbai2, Hadar A Lev-Tov3
1School of Medicine, University of California-Davis, Sacramento, California.
Journal of the American Academy of Dermatology
|November 28, 2013
Summary
Botanical agents show promise for treating epidermal hyperpigmentation, but rigorous studies are limited. Further research is needed to confirm efficacy and safety for various hyperpigmentation subtypes.
Area of Science:
- Dermatology
- Pharmacognosy
- Cosmeceuticals
Background:
- Hyperpigmentation disorders are prevalent clinical concerns.
- The cosmeceutical and natural product markets are expanding rapidly.
- Botanical agents are increasingly explored for treating hyperpigmentation.
Purpose of the Study:
- To review existing clinical evidence on botanical agents for hyperpigmentation treatment.
- To assess the quality and reproducibility of studies on botanical treatments for hyperpigmentation.
Main Methods:
- Systematic literature search of MEDLINE and Embase databases.
- Inclusion of 26 articles meeting specific criteria.
- Analysis of study methodology and grading of reproducibility.
Main Results:
- Several botanical agents demonstrate potential for lightening epidermal melasma and UV-induced hyperpigmentation.
- Methodological rigor was limited across most studies.
- Treatment outcomes for solar lentigines and dermal hyperpigmentation were mixed.
Conclusions:
- Few studies possess strong methodological design, necessitating further research.
- Hyperpigmentation subtype influences treatment response; dermal types are less responsive.
- Botanical extracts may complement standard therapies, but safety and side effects require careful consideration.
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