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Alloreactive T cells and 'the persistence of memory'

Emilio D Poggio1, Joshua J Augustine

  • 1Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Kidney International
|November 28, 2013
PubMed

Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on the presence or absence of donor-reactive effector memory T cells could influence clinical outcomes, but independent of such therapy, when 'the persistence of memory' prevails, allograft injury may occur.

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