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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Future directions in the prevention of prostate cancer

Ian M Thompson1, April B Cabang1, Michael J Wargovich1

  • 1Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, Mail Code 8026, 7979 Wurzbach, Suite 627, Zeller Building, San Antonio, TX 78229, USA.

Nature Reviews. Clinical Oncology
|November 28, 2013
PubMed

Insights

Prostate cancer chemoprevention strategies are being explored, with mixed results for supplements like selenium and vitamin E, but promising findings for 5α-reductase inhibitors. Future research will investigate new dietary and pharmacological agents.

Area of Science:

  • Oncology
  • Preventive Medicine
  • Pharmacology

Background:

  • High global incidence of prostate cancer necessitates effective prevention strategies.
  • Early chemoprevention studies with selenium and vitamin E yielded mixed results.
  • 5α-reductase inhibitors show promise in hormone-responsive prostate cancer prevention.

Purpose of the Study:

  • To review clinical and preclinical evidence for prostate cancer chemoprevention.
  • To provide an overview of current and future chemoprevention opportunities.

Main Methods:

  • Review of clinical trial data.
  • Analysis of preclinical research findings.
  • Synthesis of evidence on dietary and pharmacological interventions.

Main Results:

  • Selenium and vitamin E showed inconsistent efficacy in large-scale studies.
  • 5α-reductase inhibitors demonstrated validated efficacy in hormone-responsive prostate cancer.
  • Emerging dietary and pharmacological agents require further investigation.

Conclusions:

  • Prostate cancer chemoprevention is an evolving field with ongoing research.
  • Validated interventions like 5α-reductase inhibitors offer a path forward.
  • Further investigation is crucial for novel chemopreventive agents.

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