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Updated: May 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Current research and development of chemotherapeutic agents for melanoma
Kyaw Minn Hsan1, Chun-Chieh Chen, Lie-Fen Shyur
1Institute of Plant Biology, National Taiwan University, Taipei 106, Taiwan. lfshyur@ccvax.sinica.edu.tw.
Abstract:
Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.
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