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Related Concept Videos

Prevention of Further Absorption of Poison01:14

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Enhanced Elimination of Poison01:26

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Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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QuickTox Kit for QuickScan DON (Vomitoxin).

Andre L Albert1, Phillip D Champoux, Alan H Davis

  • 1EnviroLogix Inc., 500 Riverside Industrial Pkwy, Portland, ME 04103, USA.

Journal of AOAC International
|November 29, 2013
PubMed
Summary
This summary is machine-generated.

The QuickTox Kit accurately quantifies deoxynivalenol (DON, vomitoxin) in grains up to 5 ppm. This validated method is reliable for detecting DON contamination in wheat, maize, barley, and their products.

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Area of Science:

  • Food safety
  • Analytical chemistry
  • Mycotoxicology

Background:

  • Deoxynivalenol (DON), also known as vomitoxin, is a common mycotoxin found in cereal grains.
  • Accurate quantification of DON is crucial for ensuring food safety and compliance with regulatory limits.

Purpose of the Study:

  • To obtain AOAC Research Institute Performance Tested MethodsSM certification for the QuickTox Kit for QuickScan DON assay.
  • To validate the assay's performance for quantifying deoxynivalenol (DON) in various cereal grain commodities.

Main Methods:

  • Lateral flow technology with a reader-based system for DON quantification.
  • Testing of wheat, maize, wheat bran, wheat flour, and barley samples.
  • Evaluation of assay performance including linearity, matrix effects, selectivity, robustness, and stability.

Main Results:

  • The assay demonstrated a linear dose response (R2 > 0.97) over the 0-5.0 ppm range.
  • Repeatability (RSDr) values ranged from 3.12% to 16.01% across commodities and levels.
  • The assay showed no interference from other common mycotoxins and detected modified DON forms and nivalenol.

Conclusions:

  • The QuickTox Kit for QuickScan DON assay is a convenient and reliable method for determining DON in grain commodities.
  • The assay meets the acceptance criteria for AOAC Research Institute Performance Tested MethodsSM certification.
  • This validated method supports accurate monitoring of DON contamination in the food supply chain.