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Updated: May 5, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
Published on: December 20, 2024
Endogenous compounds labeled with radionuclides of short half-life-some perspectives
B Långström1, F Karimi, Y Watanabe
1Uppsala University, Department of Biochemistry and Organic Chemistry, Faculty of Technology and Science, Uppsala, Sweden; Imperial College, Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, London, UK; University of Southern Denmark, Institute of Clinical Research, Department of Nuclear Medicine, PET and Cyclotron Unit, Odense, Denmark.
Abstract:
In the article, the strategy and synthesis of some endogenous compounds labeled mainly with (11) C are presented. There are some examples illustrating how endogenous labeled compounds in connection with positron emission tomography have unique properties to describe various biological processes, and a few examples of the use of tracers labeled with (13) N and (15) O are also discussed. Labeled endogenous compounds may be an important asset to describe the conditions and the status of biological systems and might therefore be a key for the future search of individualized medicine.
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