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Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
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Carbon-14 labeling of K777•HCl, a therapeutic agent for Chagas disease
Sung-Whi Rhee1, Wallace W Bradford, Jeremiah P Malerich
1SRI International, Biosciences Division, 333-Ravenswood Ave, Menlo Park, CA, 94025, USA.
Journal of Labelled Compounds & Radiopharmaceuticals
|November 29, 2013
Abstract:
The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [(14) C(U)]-(l)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%.
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