Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

358
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
358
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

405
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
405
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

274
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
274
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

387
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
387
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

693
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
693
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

400
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
400

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Postoperative Radiotherapy after Primary Tumor Resection in De Novo Stage IV Breast Cancer: A Multicenter Retrospective Study (KROG 19-02).

Cancer research and treatment·2021
Same author

Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study).

Cancer research and treatment·2021
Same author

Infectious Respiratory Diseases Decreased during the COVID-19 Pandemic in South Korea.

International journal of environmental research and public health·2021
Same author

Thymoma-Associated Paraneoplastic Myositis, Presenting with Rapidly Progressive Muscle Contractures.

Journal of clinical neurology (Seoul, Korea)·2021
Same author

Surgical site infections in gynecology: the latest evidence for prevention and management.

Current opinion in obstetrics & gynecology·2021
Same author

Inter-institutional Variation in Intensity-modulated Radiotherapy for Breast Cancer in Korea (KROG 19-01).

Anticancer research·2021

Related Experiment Video

Updated: May 5, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

8.1K

Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly: a repeated panel

Mee-Ri Lee1, Hyunseung Park, Sanghyuk Bae

  • 1Department of Preventive Medicine, Seoul National University College of Medicine, , Seoul, Korea.

Journal of Epidemiology and Community Health
|November 29, 2013
PubMed
Summary

Exposure to Bisphenol A (BPA) is linked to abnormal liver function in older adults. This study highlights the need for stricter BPA controls to protect this vulnerable population from environmental toxins.

Keywords:
AGEINGENVIRONMENTAL HEALTHEPIDEMIOLOGY

More Related Videos

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

8.8K
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

3.5K

Related Experiment Videos

Last Updated: May 5, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

8.1K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

8.8K
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

3.5K

Area of Science:

  • Environmental Health
  • Toxicology
  • Gerontology

Background:

  • Bisphenol A (BPA) exposure is associated with adverse health effects in various organs.
  • While animal studies suggest liver impacts, human data on BPA's liver effects are limited.
  • This study investigates BPA's impact on liver function in the elderly.

Purpose of the Study:

  • To evaluate the relationship between urinary Bisphenol A (BPA) levels and liver function markers.
  • To assess liver function in elderly subjects with varying BPA exposure levels.
  • To determine if community-level BPA exposure affects liver health in older adults.

Main Methods:

  • A longitudinal study of 560 elderly subjects in Seoul from 2008-2010, with up to three evaluations per subject.
  • Collection of demographic, lifestyle, and environmental exposure data via questionnaires.
  • Analysis of urinary BPA concentrations and liver function tests (AST, ALT, GGT) using linear mixed and GLIMMIX models, adjusting for confounders.

Main Results:

  • Mean urinary BPA concentration was 1.13 μg/g creatinine.
  • Elevated urinary BPA levels significantly correlated with aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) (p<0.05).
  • Higher BPA concentrations were associated with a 2.66-fold increased risk of abnormal liver function (95% CI 1.15 to 5.90).

Conclusions:

  • Community-level Bisphenol A (BPA) exposure is associated with impaired liver function in the elderly population.
  • Findings suggest a need for enhanced regulatory control of BPA to safeguard susceptible groups.
  • This research underscores the public health implications of environmental BPA exposure on liver health in aging individuals.