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Updated: May 5, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
Published on: March 3, 2016
Speciation mediated by centromeres
1Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan.
Abstract:
Speciation accompanies reproductive isolation in natural populations through hybrid sterility or lethality. However, the molecular bases of hybrid lethality are mysterious. In this issue of Developmental Cell, Thomae et al. (2013) demonstrate that Drosophila speciation factors HMR and LHR form a centromeric complex and that increased dosage causes hybrid lethality.
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