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[ Fibrinolysis in diabetes mellitus]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1986
Summary
Diabetic patients exhibit diminished spontaneous fibrinolysis compared to healthy individuals. This activity is negatively correlated with blood sugar levels, emphasizing its importance in diabetes management.
Area of Science:
- Endocrinology
- Vascular Biology
- Hematology
Background:
- Diabetes mellitus is associated with vascular complications.
- Fibrinolysis plays a crucial role in maintaining vascular health.
- Altered fibrinolytic activity may contribute to diabetic microvascular complications.
Purpose of the Study:
- To investigate the activity of fibrinolysis in diabetic patients (Type I and Type II) compared to healthy controls.
- To assess the impact of venous occlusion, age, retinopathy, and disease duration on fibrinolytic activity.
- To explore the relationship between blood glucose levels and fibrinolysis in diabetes.
Main Methods:
- Investigated spontaneous and congestion-induced fibrinolysis in 198 diabetic patients and 111 healthy controls.
- A ten-minute venous occlusion test was employed.
- Correlations with age, retinopathy severity, disease duration, and blood glucose levels were analyzed.
Main Results:
- Spontaneous fibrinolysis was significantly lower in both diabetic types compared to controls.
- Fibrinolytic activity decreased with age and was lower in Type II diabetics with advanced retinopathy.
- A negative linear correlation was observed between fibrinolysis and disease duration, age, and blood glucose levels.
- Venous congestion increased fibrinolytic activity in both groups, normalizing differences between diabetics and controls.
Conclusions:
- Diabetic patients have impaired spontaneous fibrinolytic activity, which is exacerbated by higher blood glucose levels.
- Age and disease duration negatively impact fibrinolysis in diabetics.
- Fibrinolytic activity assessment in diabetics should consider blood glucose concentration.