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Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Inhibitors of Gram-positive Cell Wall Synthesis01:23

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Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
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Surface Membrane Barriers01:18

Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Updated: May 5, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
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Production and Testing of Antimicrobial Peptides and Their Mimics

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Antimicrobial peptides.

Ali Adem Bahar1, Dacheng Ren

  • 1Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA. dren@syr.edu.

Pharmaceuticals (Basel, Switzerland)
|November 30, 2013
PubMed
Summary

Drug-resistant infections demand new treatments. Antimicrobial peptides (AMPs) offer a promising alternative to antibiotics, targeting a broad range of pathogens and overcoming resistance.

Area of Science:

  • Microbiology
  • Biochemistry
  • Drug Discovery

Background:

  • Rising antimicrobial resistance poses a global health threat.
  • Conventional antibiotics are increasingly ineffective against resistant pathogens like "superbugs".
  • There is an urgent need for novel therapeutic strategies to combat infectious diseases.

Purpose of the Study:

  • To review the history and recent advancements in antimicrobial peptides (AMPs).
  • To explore the mechanisms of action and resistance related to AMPs.
  • To discuss the potential of AMPs in treating drug-resistant infections, including biofilms and persister cells.

Main Methods:

  • Literature review of antimicrobial peptides.
  • Analysis of AMPs' modes of action and resistance mechanisms.

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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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Production and Testing of Antimicrobial Peptides and Their Mimics
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Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
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  • Discussion of AMP design principles and applications.

    • Main Results:

    • Antimicrobial peptides (AMPs) are a diverse class of molecules with broad-spectrum activity.
    • AMPs exhibit various mechanisms of action against viruses, bacteria, fungi, and parasites.
    • Mechanisms of resistance to AMPs have been identified, alongside strategies for overcoming them.

    Conclusions:

    • Antimicrobial peptides (AMPs) represent a promising therapeutic avenue against drug-resistant infections.
    • Effective design principles can enhance AMP efficacy and overcome resistance.
    • AMPs show significant potential for controlling challenging bacterial structures like biofilms and persister cells.