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Gender differences in Iranian patients with ankylosing spondylitis
Abtin Shahlaee1, Mahdi Mahmoudi, Mohammad Hossein Nicknam
1Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, P.O. Box 1411713137, Kargar Ave., Tehran, Iran.
Clinical Rheumatology
|November 30, 2013
Summary
Gender influences ankylosing spondylitis (AS) presentation. While disease severity was similar, women showed higher enthesitis rates, indicating potential gender-specific diagnostic delays and the need for early detection in AS patients.
Area of Science:
- Rheumatology
- Immunogenetics
- Clinical Medicine
Background:
- Ankylosing spondylitis (AS) exhibits gender-based variations in disease features and severity.
- Understanding these differences is crucial for assessing gender's impact on AS progression and clinical outcomes.
Purpose of the Study:
- To investigate the influence of gender on disease patterns, clinical manifestations, and treatment in Iranian patients with ankylosing spondylitis (AS).
Main Methods:
- A cohort of 320 primary AS patients (67 women, 253 men) was analyzed for demographic, clinical, HLA-B27 status, disease severity, functional capacity, quality of life, and treatment.
- Statistical analysis compared disease characteristics between genders.
Main Results:
- Males had higher HLA-B27 frequency (78.3% vs. 55.2%).
- Females exhibited a higher prevalence of enthesitis (p<0.05).
- Disease severity, extra-articular manifestations, and treatment modalities were similar, but females showed more severe disease in some aspects.
Conclusions:
- Gender does not significantly alter overall AS severity or diagnostic delay in this Iranian cohort.
- Higher enthesitis rates in women warrant further investigation into gender-specific disease mechanisms.
- Despite similar disease activity, findings suggest a need for improved early diagnosis and specialized care for AS patients in the region.
