Related Experiment Video
Updated: May 5, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Paediatric post-septal and pre-septal cellulitis: 10 years' experience at a tertiary-level children's hospital
A V Mathew1, E Craig, R Al-Mahmoud
1Department of Radiology, Royal Hallamshire Hospital, Sheffield, UK.
Insights
Orbital cellulitis (post-septal cellulitis) is common, often linked to sinus disease, and carries a risk of serious complications. CT imaging, including coronal views and head scans, is crucial for diagnosis and management.
Area of Science:
- Ophthalmology
- Radiology
- Infectious Diseases
Background:
- Pre-septal cellulitis (pre-SC) and post-septal cellulitis (post-SC), also known as periorbital and orbital cellulitis, are common conditions requiring accurate diagnosis.
- Paranasal sinus disease (PNS) is frequently associated with pre-SC and post-SC, increasing the risk of complications.
Purpose of the Study:
- To determine the incidence and complication rates of pre-SC and post-SC over a 10-year period.
- To evaluate the diagnostic utility of CT scans in identifying pre-SC, post-SC, associated PNS, and complications.
Main Methods:
- Retrospective analysis of CT scans from 125 patients suspected of having pre-SC or post-SC.
- Data collected included the presence of pre-SC and post-SC, PNS, and any identified complications.
- CT scans involved post-contrast orbits and head with multiplanar reformats, focusing on the superior ophthalmic vein (SOV) and cavernous sinus.
Main Results:
- Of 125 patients, 71 (57%) had post-SC, and 104 (83%) had PNS.
- Orbital abscesses occurred in 50 patients (40%), predominantly in the medial orbit (88%).
- Serious complications, including superior ophthalmic vein (SOV) thrombosis, cavernous sinus thrombosis (CST), and subdural empyema, were observed in 5 patients (7%).
Conclusions:
- Post-SC is frequently associated with PNS and carries a significant risk of orbital abscess and major intracranial complications.
- CT imaging with coronal reformats is essential for detecting orbital abscesses, especially those in the superior or inferior orbits.
- Prompt CT evaluation of the orbits, head, and cavernous sinus is recommended for suspected post-SC to identify potential intracranial complications and guide urgent multidisciplinary management.
Objective:
To assess the incidence and complications of pre-septal (pre-SC) and post-septal (post-SC) cellulitis over 10 years. Pre-SC and post-SC are also known as periorbital and orbital cellulitis, respectively.
Methods:
Retrospective analysis of CT scans. Data included the presence of pre-SC and post-SC, paranasal sinus disease (PNS) and complications.
Results:
Among 125 patients scanned for these suspected diagnoses, 67 had both pre-SC and post-SC, 37 had pre-SC and 4 had post-SC; there were 17 normal scans. 110 patients had PNS. 68/71 (96%) patients with post-SC had PNS. Post-SC complications included orbital and/or subperiosteal abscess (50/71: 30 medial orbital, 10 superomedial, 3 lateral, 2 anteromedial, 2 inferomedial, 1 superior, 1 anterosuperior and 1 not specified), cavernous sinus thrombosis (CST) (1), superior ophthalmic vein (SOV) thrombosis (4) and subdural frontal empyema (2); 1 patient had SOV and CST and subdural empyema.
Conclusion:
71/125 (57%) patients had post-SC. 50/125 (40%) patients imaged for pre-SC/post-SC had orbital abscess; 44/50 (88%) of these involved the medial orbit. Patients can develop solely superior or inferior abscesses that are difficult to identify by axial imaging alone, hence coronal reformatted imaging is essential. 5/125 (4%) patients developed major complications (SOV/CST/empyema), hence imaging review of the head and cavernous sinus region is essential. A diagnosis of post-SC on CT should alert the radiologist because this diagnosis can be associated with an increased incidence (5/71, 7%) of complications.
Advances In Knowledge:
We recommend that all patients with a suspected diagnosis of post-SC should undergo CT scan (post-contrast orbits and post-contrast head, with multiplanar reformats and a careful review of the SOV and the cavernous sinus). Particular attention should be paid to exclude intracranial complications including subdural empyema and cerebral abscess. As soon as a diagnosis of post-SC is made, in addition to informing the referring clinical team, urgent opinion should be sought from ear, nose and throat (ENT), neurology and ophthalmology with a view to urgently drain of the paranasal sinuses`.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Brain Abscess l: Introduction
Tonsillitis II: Management
Bacterial Meningitis I: Introduction
Pharmacokinetics in Pediatric Patients: Drug Excretion

