Correlation between antibodies to gonadotropin-releasing hormone and reproductive disorders in humans
I V Menzhinskaya1, L V Van'ko, P A Kiryushchenkov
1V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care of the Russian Federation, Moscow, Russia. i_menzhinskaya@oparina4.ru.
Abstract:
Antibodies (IgG) to gonadotropin-releasing hormone were measured by ELISA in blood serum of women with miscarriage and men with infertility. Spontaneous production of antibodies to gonadotropin-releasing hormone was observed during miscarriage and male infertility: the mean level of antibodies in these groups was higher than in healthy women and men (p<0.0001). ROC-analysis showed that test for IgG to gonadotropin-releasing hormone has high sensitivity, specificity, and AUC (more that 70%, 90%, and 0.8, respectively). Thus, the presence of antibodies to gonadotropin-releasing hormone was associated with impairments of human reproductive function.
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