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Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
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Antithrombogenic activity of antioxidant compounds
A A Spasov1, A F Kucheryavenko, V A Kosolapov
1Department of Pharmacology, Volgograd State Medical University; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia. aspasov@mail.ru.
Bulletin of Experimental Biology and Medicine
|November 30, 2013
Summary
Enoxifol, an antioxidant with anti-clotting properties, showed superior antithrombotic effects compared to mexidol and acetylsalicylic acid in a rat thrombosis model. Its dual antioxidant and anti-aggregant actions likely contribute to its efficacy.
Area of Science:
- Pharmacology
- Cardiovascular Research
- Biochemistry
Background:
- Thrombosis is a significant cause of cardiovascular disease.
- Developing novel antithrombotic agents with antioxidant properties is crucial.
- Enoxifol and Mexidol are antioxidants with potential anti-aggregant activities.
Purpose of the Study:
- To compare the antithrombotic activities of enoxifol and mexidol.
- To evaluate their efficacy against acetylsalicylic acid, a reference anti-aggregant drug.
- To investigate the role of antioxidant and anti-aggregant properties in antithrombotic effects.
Main Methods:
- A rat model of arterial thrombosis induced by ferric chloride.
- Administration of enoxifol, mexidol, and acetylsalicylic acid in varying doses.
- Assessment of dose-dependent antithrombotic activity.
Main Results:
- All tested drugs demonstrated dose-dependent antithrombotic activity.
- Enoxifol exhibited greater efficacy than mexidol.
- Both enoxifol and mexidol were more effective than acetylsalicylic acid.
Conclusions:
- Enoxifol possesses significant antithrombotic activity, surpassing both mexidol and acetylsalicylic acid.
- The potent antithrombotic effect of enoxifol is likely attributed to its combined antioxidant and anti-aggregant properties.
- Enoxifol represents a promising candidate for further investigation as an antithrombotic agent.
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