Related Experiment Video
Updated: May 5, 2026

08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
3.8K
Acute exertional rhabdomyolysis
1Department of Orthopedic Surgery, Seoul Paik Hospital, Seoul, Republic of Korea.
The Journal of Orthopaedic and Sports Physical Therapy
|December 3, 2013
Summary
A young military member experienced severe leg pain after intense squatting, leading to a diagnosis of rhabdomyolysis. This condition involves muscle breakdown and can be triggered by strenuous physical activity.
Area of Science:
- Orthopaedic Surgery
- Sports Medicine
- Exercise Physiology
Background:
- Acute exertional rhabdomyolysis is a medical condition involving skeletal muscle breakdown.
- It is often associated with strenuous or unaccustomed physical activity.
- Early diagnosis and management are crucial to prevent complications.
Observation:
- A 21-year-old military service member presented with severe bilateral lower extremity pain.
- The pain onset was 2 days prior, following repetitive and vigorous squatting exercises.
- The patient's symptoms raised concern for acute exertional rhabdomyolysis.
Findings:
- Laboratory tests were performed to assess for muscle damage markers.
- Diagnostic imaging, including scintigraphy and MRI, was utilized.
- Results from laboratory testing and imaging were consistent with a diagnosis of rhabdomyolysis.
Implications:
- This case highlights the risk of rhabdomyolysis in military personnel undergoing intense training.
- Prompt recognition of exertional rhabdomyolysis is essential for appropriate patient care.
- Understanding the precipitating factors can inform injury prevention strategies in physically demanding occupations.
Related Concept Videos
Acute Kidney Injury I: Introduction
1.5K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.5K
Muscle Recovery and Fatigue
4.5K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.5K
Acute Kidney Injury III: Clinical Manifestations
1.8K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.8K
Cytotoxic Edema: Pathophysiology
31
Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous...
31
Nephrotic Syndrome I : Introduction
1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Acute Kidney Injury II: Pathophysiology
2.4K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.4K

