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Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers

Woraphat Ratta-apha¹, Akitoyo Hishimoto¹, Kentaro Mouri¹

¹Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.

Psychiatry Research

|December 3, 2013

Abstract:

The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.

Keywords:

Completed suicide Disrupted-in-schizophrenia 1 Haplotype analysis

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