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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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[In-vivo analysis for human brain maturation using MRI].

Yuji Suzuki1

  • 1Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata.

Rinsho Shinkeigaku = Clinical Neurology
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Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (MRS) offer non-invasive insights into brain maturation. These MRI techniques reveal changes in white matter and neurotransmitters, aiding the study of neurodevelopmental disorders.

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Area of Science:

  • Neuroscience
  • Medical Imaging

Context:

  • Evaluating human brain maturation in vivo is crucial for pediatric neurology.
  • Non-invasive Magnetic Resonance Imaging (MRI) techniques like Diffusion Tensor Imaging (DTI) and (1)H-MR Spectroscopy (MRS) show promise for assessing brain development.

Purpose:

  • To investigate the utility of DTI and MRS in characterizing in vivo human brain maturation.
  • To correlate imaging findings with known maturational changes like myelination and synaptic refinement.

Summary:

  • DTI revealed decreased eigenvalues and increased Fractional Anisotropy in frontal and parietal white matter during maturation, reflecting changes in neural fibers and myelination.
  • (1)H-MR Spectroscopy (MRS) showed a decreased glutamate/creatine ratio, indicating synaptic refinement, but no change in the N-acetyl-aspartate/creatine ratio.
  • Combined, DTI and MRS provide quantitative, non-invasive data on brain maturation.

Impact:

  • These MRI techniques can offer direct insights into normal and abnormal brain development.
  • This approach may help elucidate the pathophysiology of neurodevelopmental disorders affecting brain maturation.
  • Facilitates objective monitoring of brain development in pediatric populations.