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[Fisher syndrome and Bickerstaff brainstem encephalitis]
1Department of Neurology, Chiba University.
Rinsho Shinkeigaku = Clinical Neurology
|December 3, 2013
Summary
Fisher syndrome and Bickerstaff brainstem encephalitis are now viewed as a single spectrum of inflammatory neuropathy. The presence of anti-GQ1b IgG antibodies supports this unified disease classification.
Area of Science:
- Neurology
- Neuroimmunology
- Inflammatory Neuropathies
Context:
- Fisher syndrome and Bickerstaff brainstem encephalitis (BBE) are distinct neurological disorders.
- Fisher syndrome involves ophthalmoplegia, ataxia, and areflexia.
- BBE is characterized by ophthalmoplegia, ataxia, and consciousness disturbance.
Purpose:
- To re-evaluate the classification of Fisher syndrome and Bickerstaff brainstem encephalitis.
- To explore the relationship between these two neurological conditions.
- To highlight the role of anti-GQ1b IgG antibodies in their pathogenesis.
Summary:
- Both Fisher syndrome and BBE share features like preceding infections, albumin-cytological dissociation, and association with Guillain-Barre syndrome.
- The identification of anti-GQ1b IgG antibodies provides a unifying biomarker.
- BBE is now considered a variant of Fisher syndrome with central nervous system involvement.
Impact:
- This reclassification offers a clearer understanding of a spectrum of inflammatory neuropathies.
- It may guide diagnostic approaches and therapeutic strategies for affected patients.
- Advances understanding of neuroimmunological disorders affecting the central and peripheral nervous systems.
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