Posterior reversible encephalopathy syndrome due to pulse methylprednisolone therapy in a child

Faruk İncecik1, M Özlem Hergüner, Dinçer Yıldızdaş

  • 1Division of Pediatric Neurology, Department of Pediatrics, Çukurova University Faculty of Medicine, Adana, Turkey. fincecik@yahoo.com.

Insights

Posterior reversible encephalopathy syndrome (PRES) is a neurological condition. This case study highlights PRES as a complication of pulse methylprednisolone therapy in an eight-year-old boy.

Area of Science:

  • Neurology
  • Radiology
  • Pediatrics

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder characterized by specific radiological findings.
  • PRES is associated with various conditions including medications, renal disease, autoimmune disorders, transplantation, and sepsis in children.

Observation:

  • This report details an eight-year-old boy diagnosed with PRES.
  • The patient experienced PRES during pulse methylprednisolone therapy.

Findings:

  • PRES is identified as a neurological complication linked to pulse methylprednisolone treatment.
  • The condition demonstrated a positive response to immediate cessation of the therapy and management of blood pressure.

Implications:

  • Early recognition and management of PRES are crucial for favorable outcomes.
  • This case underscores the importance of monitoring for PRES in pediatric patients receiving pulse methylprednisolone therapy.

Related Concept Videos

Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
30
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
47
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
71