[Identification of osteogenic signal and the development of artificial bones]
Shinsuke Ohba1, Ung-il Chung, Yuichi Tei
1Department of Bioengineering, The University of Tokyo Graduate School of Engineering, Japan.
Abstract:
Mammalian skeletons are formed through two distinct processes, intramembranous ossification and endochondral ossification. During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and the layer of hypertrophic chondrocytes. Ihh also stimulates bone formation. Based on such knowledge, bioactive molecule-loaded artificial bones are expected to achieve efficient bone regeneration without cell transplantation.
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