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Left ventricular systolic and diastolic function in subjects with a bicuspid aortic valve without significant
1Cardiology Department, Bursa Yüksek htisas Education and Research Hospital, Bursa, Turkey.
Experimental and Clinical Cardiology
|December 3, 2013
Summary
Bicuspid aortic valve (BAV) is linked to impaired left ventricular systolic and diastolic function, as evidenced by lower ejection fraction and altered diastolic velocities in affected individuals. This suggests BAV may be associated with cardiac dysfunction.
Area of Science:
- Cardiology
- Genetics
- Echocardiography
Background:
- Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect in adults.
- BAV is commonly associated with ascending aorta dilation, aneurysm, and dissection.
Purpose of the Study:
- To assess left ventricular systolic and diastolic function in individuals with BAV.
- To compare cardiac function parameters between BAV subjects and healthy controls.
Main Methods:
- Echocardiography, including tissue Doppler, was used to evaluate cardiac function.
- Thirty-five BAV subjects and 30 age- and sex-matched controls were analyzed.
- Systolic and diastolic parameters were compared between the BAV and control groups.
Main Results:
- BAV subjects exhibited a lower left ventricular ejection fraction compared to controls.
- Altered mitral inflow and myocardial diastolic velocities were observed in BAV patients.
- Higher myocardial performance index and increased prevalence of mitral valve prolapse and atrial septal aneurysms were noted in BAV group.
Conclusions:
- Bicuspid aortic valve may be associated with impaired left ventricular systolic and diastolic function.
- These findings highlight potential cardiac complications in individuals with BAV.
Keywords:
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