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Hematological parameters and coronary collateral circulation in patients with stable coronary artery disease
Selim Ayhan1, Serkan Ozturk, Alim Erdem
1Abant Izzet Baysal University School of Medicine, Department of Cardiology, Bolu, Turkey.
Insights
Hematological parameters like neutrophil/lymphocyte ratio and mean platelet volume are linked to poor coronary collateral circulation in stable coronary artery disease patients. A high neutrophil/lymphocyte ratio predicts inadequate collateral development.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Hematological parameters influence prognosis in cardiovascular diseases.
- The association between hematological markers and coronary collateral (CC) circulation in stable coronary artery disease (CAD) remains unclear.
Purpose of the Study:
- To examine the relationship between hematological parameters and CC vessel development in patients with stable CAD.
- Investigate if mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio correlate with CC formation.
Main Methods:
- Retrospective analysis of 96 stable CAD patients with occluded coronary arteries.
- Coronary angiography used to assess CC development (Rentrop grades).
- Multivariate logistic regression identified independent predictors of CC circulation.
Main Results:
- Higher MPV and N/L ratios were observed in patients with poor CCs (Rentrop grades 0-1).
- Significant negative correlations found between Rentrop score and both MPV and N/L ratio.
- N/L ratio independently predicted poor CC development (OR 0.762, P=0.04).
Conclusions:
- Neutrophil/lymphocyte ratio and MPV are associated with diminished coronary collateral circulation.
- Elevated N/L ratio is a significant predictor of poor CC development in stable CAD.
Background:
Although hematological parameters have been associated with prognosis in patients with various cardiovascular diseases, their relationship with coronary collateral (CC) circulation in patients with stable coronary artery disease (CAD) is unknown.
Objective:
To investigate the relationship between hematological parameters and CC vessel development in patients with stable CAD.
Methods:
A total of 96 patients who underwent coronary angiography were retrospectively enrolled. All study participants had at least one occluded major coronary artery. Development of CCs was classified using the method of Rentrop. Rentrop grades of 0 and 1 indicate poor CCs, whereas grades 2 and 3 indicate good CCs. Hematological parameters, including mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio, were measured. Multivariate logistic regression analysis was performed to identify independent variables.
Results:
The MPV and N/L ratio were significantly higher in the poor CC group compared with the good CC group. Negative correlations were found in the analyses comparing Rentrop score with MPV and N/L ratio (r=-0.274; P=0.012 and r=-0.339; P=0.001, respectively). In multivariate analysis, the N/L ratio was independently related to CC circulation (OR 0.762 [95% CI 0.587 to 0.988]; P=0.04).
Conclusion:
The results suggest that N/L ratio and MPV are associated with poor CCs, and a high N/L ratio is a significant predictor of poor CC development in patients with stable CAD.
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