[Cross-autoimmune syndromes in hepatology]

Along with the traditional autoimmune liver diseases--autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC)--in clinical practice there are syndromes of autoimmune decussating. The term cross-syndrome means that in one patient there are signs of two different autoimmune liver diseases, that probably have a common pathogenesis. In line with the literature data and own experience of the diagnostic criteria there are different cross-syndromes: AIH and PBC, AIH and PSC; and also a combination of AIH and chronic hepatitis C. The most appropriate combinations and doses of prednisolone (budesonid), azathioprine and ursodesoxycholic acid, recommended for treatment of various options of cross-syndrome, as well as medical tactics in view of the conjunction of AIH and chronic hepatitis C, have been considered.