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Determining optimal noninvasive parameters for the prediction of left ventricular remodeling in chronic ischemic
Frank Rademakers1, Jan Engvall, Thor Edvardsen
1University Hospitals Leuven and KU Leuven, Department of Cardiovascular Sciences , Leuven , Belgium.
Insights
The DOPPLER-CIP study identifies optimal noninvasive cardiac imaging methods to predict outcomes in ischemic heart disease patients. This research will guide cost-effective healthcare strategies for managing ventricular remodeling and recovery.
Area of Science:
- Cardiology
- Medical Imaging
- Translational Research
Background:
- Chronic ischemic heart disease poses significant challenges in predicting adverse ventricular remodeling and functional recovery.
- Current noninvasive parameters for assessing myocardial function, perfusion, and cell integrity vary in their predictive value and cost-effectiveness.
Purpose of the Study:
- To determine optimal noninvasive parameters and imaging methodologies for predicting the impact of interventions on ventricular remodeling and functional recovery in ischemic heart disease.
- To evaluate the relative predictive value and cost-effectiveness of various noninvasive parameters.
Main Methods:
- A multi-center registry study (DOPPLER-CIP) involving patients with ischemic heart disease.
- Baseline assessment using at least two noninvasive stress imaging examinations (ergometry, echocardiography, scintigraphy, MRI).
- Assessment of left ventricular (LV) remodeling and cardiac events over a 2-year follow-up period.
Main Results:
- 676 patients were included in the study.
- Baseline data analysis is nearing completion, with patient follow-up currently ongoing.
- The study is actively collecting data on cardiac events and ventricular remodeling.
Conclusions:
- Upon completion, DOPPLER-CIP will establish evidence-based guidelines for the effective utilization of cardiac imaging in patients with chronic ischemic heart disease.
- The project will yield new insights into novel imaging methodologies and the pathophysiology of chronic ischemic heart disease.
- Findings will support optimized, cost-effective healthcare decisions in managing ischemic heart disease.
Objectives:
DOPPLER-CIP aims to determine the optimal noninvasive parameters (myocardial function, perfusion, ventricular blood flow, cell integrity) and methodology (ergometry, echocardiography, scintigraphy, MRI) in a given ischemic substrate that best predicts the impact of an intervention (or the lack thereof) on adverse morphological ventricular remodeling and functional recovery. Moreover, the relative predictive value of each of these parameters, in respect to the cost of extracting this information in order to enable optimization of cost-effectiveness for improved health care, will be determined by this project.
Design:
DOPPLER-CIP is a multi-center registry study. All patients with ischemic heart disease included in this study undergo at least two noninvasive stress imaging examinations at baseline. The presence/or absence of left ventricular (LV) remodeling will be assessed after a follow-up of 2 years, during which all cardiac events will be registered.
Results:
676 patients were included. Currently, baseline data analysis is almost finished and the follow-up is ongoing.
Conclusions:
After completion, DOPPLER-CIP will provide evidence-based guidelines toward the most effective use of cardiac imaging in the chronically ischemic heart disease patient. The study will generate information, knowledge, and insight into the new imaging methodologies and into the pathophysiology of chronic ischemic heart disease.
