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Updated: May 5, 2026

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Bioengineered alternative tissues.

Emily A Cook¹, Jeremy J Cook, Homan Badri

¹Mount Auburn Hospital, Harvard Medical School, Cambridge, MA 02138, USA.

Clinics in Podiatric Medicine and Surgery

|December 4, 2013

Summary

This summary is machine-generated.

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Bioengineered alternative tissues (BATs) advance diabetic foot ulcer treatment. Regenerating cells to a prenatal state could revolutionize tissue repair and wound closure strategies.

Area of Science:

Biomaterials science
Regenerative medicine
Tissue engineering

Background:

Bioengineered alternative tissues (BATs) are advanced materials for healing diabetic foot ulcers.
Significant progress in BAT development and clinical application has occurred in the past decade.
BATs can be sourced from autografts, allografts, or xenografts and may be single- or bilayered.

Purpose of the Study:

To review the current state of bioengineered alternative tissues for diabetic foot ulcers.
To highlight advancements in the development and clinical use of BATs.
To explore future directions in cellular regeneration for tissue replacement.

Main Methods:

Literature review of recent advancements in BATs.
Analysis of different BAT sources (autograft, allograft, xenograft).

Keywords:

Acellular Bioengineered Cellular Diabetic Ulcer skin

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Last Updated: May 5, 2026

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

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Published on: April 21, 2016

Examination of BAT structures (single-layer epidermal/dermal, bilayer).

Main Results:

BATs show promise in aiding wound closure for diabetic foot ulcers.
Diverse sources and compositions of BATs are available for clinical use.
Current BATs represent significant progress but are not the ultimate solution for tissue replacement.

Conclusions:

Continued innovation in BATs is crucial for improving diabetic foot ulcer treatment.
Achieving cellular regeneration by reverting cells to a prenatal state is a key future goal.
This breakthrough could revolutionize tissue replacement and regenerative medicine.