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Updated: May 5, 2026

Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro-in vivo evaluations
Jadupati Malakar1, Prabir Kumar Datta1, Saikat Das Purakayastha1
1Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur 713212, West Bengal, India.
Abstract:
The present study deals with the development and evaluations of stomach-specific floating capsules containing salbutamol sulfate-loaded oil-entrapped alginate-based beads. Salbutamol sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10h (R10 h) from capsules was analyzed by 3(2) factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R10 h of 56.96 ± 2.92%. These capsules showed floatation over 6h and sustained drug release over 10h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
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