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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study
Özgür Bilgin Yiyenoğlu1, Mete Gürol Uğur, Hüseyin Çağlayan Özcan
1Department of OB&GYN, Faculty of Medicine, Gaziantep University, Sahinbey, Turkey.
Objective:
To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method.
Materials And Methods:
30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method.
Results:
We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013).
Conclusion:
Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed.
