Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent treatment outcomes of cervical intraepithelial neoplasia in south western Uganda: a six year retrospective study.

Gynecologic oncology reports·2026
Same author

Detection of mutant cancer-derived circRNAs in extracellular vesicles by rolling circle amplification.

Molecular therapy. Nucleic acids·2026
Same author

Hydrogel-based multiplexed high-risk human papillomavirus DNA/RNA detection for cervical cancer screening.

Biosensors & bioelectronics: X·2026
Same author

Self-amplifying CRISPR-based one-pot ultrasensitive testing for rapid SARS-CoV-2 and its variant detection.

Biosensors & bioelectronics·2026
Same author

Smartphone-based preeclampsia diagnosis through detection of dual biomarkers - nephrin and podocalyxin.

Biosensors & bioelectronics·2026
Same author

Impact of a mobile health education program on blood pressure and lipid profiles: a cohort study.

BMC public health·2026
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
05:58

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

2.0K

Ascites analysis by a microfluidic chip allows tumor-cell profiling.

Vanessa M Peterson1, Cesar M Castro, Jaehoon Chung

  • 1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.

Proceedings of the National Academy of Sciences of the United States of America
|December 4, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a microfluidic chip for isolating ovarian cancer ascites tumor cells (ATCs). This method enables sensitive monitoring of treatment response, potentially replacing invasive biopsies.

Keywords:
biomarkersmolecular profilingpersonalized medicine

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

14.5K
Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

990

Related Experiment Videos

Last Updated: May 5, 2026

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
05:58

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

2.0K
A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

14.5K
Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

990

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Molecular Diagnostics

Background:

  • Ascites tumor cells (ATCs) offer a non-invasive source for monitoring ovarian cancer treatment.
  • Current methods often require invasive surgical biopsies, limiting longitudinal studies.
  • Point-of-care testing of ascites could revolutionize clinical trials and patient care.

Purpose of the Study:

  • To develop a microfluidic platform for enriching ATCs from peritoneal fluid.
  • To identify and validate reliable protein markers for ATC detection and quantification.
  • To assess the utility of enriched ATCs for monitoring ovarian cancer treatment response.

Main Methods:

  • Development of a microfluidic chip for efficient ATC enrichment from heterogeneous ascites.
  • Evaluation of 85 potential ovarian cancer protein markers for specificity and abundance.
  • Prospective study of 47 patients using a validated four-marker panel (ATCdx).

Main Results:

  • The microfluidic platform successfully enriches ATCs, enabling molecular analysis.
  • A panel of four markers (ATCdx) was identified as sensitive and specific for mapping ATC numbers.
  • The method facilitates monitoring of treatment response markers like proliferation and pathway inhibition.

Conclusions:

  • The developed microfluidic chip and ATCdx marker set provide a sensitive and specific tool for non-invasive ovarian cancer monitoring.
  • This approach can significantly impact ovarian cancer clinical trials and patient management by enabling longitudinal assessment.
  • Enriched ATCs can be used for evaluating treatment efficacy through various molecular analyses.