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Bronchial hyperresponsiveness in patients with obstructive sleep apnea syndrome
Emel Bulcun1, Mehmet Ekici, Aydanur Ekici
1Department of Chest Diseases, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey. emelbulcun@hotmail.com.
Tuberkuloz Ve Toraks
|December 5, 2013
Summary
Bronchial hyperresponsiveness (BHR) is common in obstructive sleep apnea syndrome (OSAS) patients. Increased OSAS severity correlates with greater BHR severity, and obesity may contribute to BHR development.
Area of Science:
- Pulmonary Medicine
- Sleep Medicine
- Respiratory Physiology
Background:
- The link between obstructive sleep apnea syndrome (OSAS) and bronchial hyperresponsiveness (BHR) remains unclear.
- This study investigates the association between BHR and OSAS severity.
Purpose of the Study:
- To explore the relationship between bronchial hyperresponsiveness and disease severity in patients diagnosed with obstructive sleep apnea syndrome.
Main Methods:
- Forty-seven OSAS patients underwent polysomnography and histamine bronchial challenge tests.
- Body mass index (BMI) and Epworth sleepiness scale (ESS) scores were recorded.
- Bronchial provocative testing (BPT) positivity defined BHR (PD values ≤ 16 mg/mL).
Main Results:
- BHR was present in 21 out of 47 OSAS patients.
- Higher apnea-hypopnea index (AHI), BMI, and ESS scores were observed in patients with BHR.
- Significant negative correlations were found between PD 20 values and AHI, BMI, and ESS scores.
Conclusions:
- Bronchial hyperresponsiveness is prevalent in OSAS patients.
- Increased OSAS severity is associated with increased BHR severity.
- Obesity may be a contributing factor to the presence of BHR in OSAS.
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