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Related Experiment Video

Updated: May 5, 2026

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Published on: July 8, 2025

Fluorescent aptasensor based on aggregation-induced emission probe and graphene oxide.

Xing Li¹, Ke Ma, Shoujun Zhu

¹State Key Laboratory of Supramolecular Structure and Materials, Jilin University , 2699 Qianjin Avenue, Changchun, Jilin 130012, P. R. China.

Analytical Chemistry

|December 5, 2013

Summary

This study introduces a novel fluorescent probe for highly selective and sensitive detection of DNA and thrombin protein. The developed aptasensor overcomes limitations of previous methods by minimizing nonspecific binding for improved accuracy.

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Last Updated: May 5, 2026

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Area of Science:

Biochemistry
Materials Science
Analytical Chemistry

Background:

Aggregation-induced emission (AIE) probes are widely used for sensitive biosensing.
Existing AIE-based aptasensors suffer from poor selectivity due to nonspecific binding.
There is a need for selective and sensitive aptasensors for biomolecule detection.

Discussion:

A novel AIE probe, 9,10-distyrylanthracene with two ammonium groups (DSAI), was synthesized.
A fluorescent aptasensor was developed using DSAI and graphene oxide (GO).
The aptasensor demonstrates high selectivity and sensitivity for targeted DNA and thrombin protein detection.

Key Insights:

The synthesized DSAI probe exhibits AIE properties.
The DSAI-GO aptasensor effectively distinguishes between target and non-target molecules.
Nonspecific binding issues common in AIE aptasensors were significantly reduced.

Outlook:

The developed aptasensor shows potential for detecting other biological targets.
This work provides a new strategy for designing selective AIE-based biosensors.
Further research can explore the application of this aptasensor in complex biological samples.