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MR Spectroscopy Findings in Lhermitte-Duclos Disease. A Case Report
1Kocaeli University School of Medicine, Radiology Department; Umuttepe Kocaeli, Turkey - yoncaanik@yahoo.com.
The Neuroradiology Journal
|December 5, 2013
Summary
Lhermitte-Duclos disease (LDD) is a rare cerebellar enlargement. Magnetic resonance imaging (MRI) and spectroscopy (MRS) help confirm its benign hamartomatous nature.
Area of Science:
- Neurology
- Radiology
- Oncology
Background:
- Lhermitte-Duclos disease (LDD) is a rare cerebellar disorder characterized by abnormal tissue growth.
- Its etiology remains unclear, presenting as a focal or diffuse enlargement of the cerebellum.
Purpose of the Study:
- To report a case of Lhermitte-Duclos disease.
- To describe the characteristic magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) findings.
Main Methods:
- Review of a LDD case.
- Analysis of MRI scans for characteristic features like non-enhancing, striated cerebellar masses.
- Evaluation of MRS data, including N-acetyl aspartate, lactate, and choline levels.
Main Results:
- MRI revealed a non-enhancing cerebellar mass with a striated pattern, consistent with LDD.
- MRS findings showed decreased N-acetyl aspartate and increased lactate, supporting a benign hamartomatous nature.
- The lesion exhibited slow-growing behavior.
Conclusions:
- MRI and MRS are crucial for diagnosing LDD.
- MRS findings aid in confirming the benign hamartomatous nature of LDD, differentiating it from other cerebellar pathologies.
