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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

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Multiple norovirus infections in a birth cohort in a Peruvian Periurban community

Mayuko Saito1, Sonia Goel-Apaza, Susan Espetia

  • 1Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 5, 2013
PubMed

Insights

Human norovirus infections are common in infants, causing diarrhea and impacting growth. Serial infections with multiple genotypes suggest a need for multi-genotype vaccines to reduce childhood illness.

Area of Science:

  • Pediatric Infectious Diseases
  • Gastroenterology
  • Public Health Epidemiology

Background:

  • Human noroviruses are a leading cause of infant diarrhea globally, particularly in developing nations.
  • Community-level impact data for norovirus infections remain limited.
  • Infant diarrhea significantly contributes to childhood morbidity in resource-limited settings.

Purpose of the Study:

  • To estimate the incidence of norovirus infection and associated diarrhea in a Peruvian birth cohort.
  • To characterize norovirus genogroups, genotypes, and excretion duration in young children.
  • To assess the impact of norovirus infection on child growth and development.

Main Methods:

  • A birth cohort study followed children to assess norovirus infection and diarrhea incidence.
  • Polymerase chain reaction (PCR) was used to detect norovirus genogroup and genotype in stool samples.
  • Excretion duration and rotavirus coinfection were analyzed in a subset of episodes.

Main Results:

  • By age two, 71% of children experienced norovirus-associated diarrhea, with Genogroup II (GII) infections being most frequent.
  • Eighteen genotypes were identified, with GII genotype 4 being the most prevalent (41%).
  • Norovirus infection was associated with lower length-for-age z scores at 12 and 24 months.

Conclusions:

  • Norovirus infections are acquired early in life, with children experiencing repeated infections by different genotypes.
  • Findings suggest genotype-specific immunity, indicating a need for multi-genotype vaccines.
  • Vaccination strategies targeting multiple norovirus genotypes could significantly reduce childhood morbidity.
Abstract

Keywords:
birth cohortgastroenteritisinfant diarrheanatural infectionnorovirus

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