Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Efficacy of Topical Vitamin C on the Appearance of Wrinkles: A Systematic Literature Review

Journal of drugs in dermatology : JDD·2023
Same author

The Contest of Nanoparticles: Searching for the Most Effective Topical Delivery of Corticosteroids.

Pharmaceutics·2023
Same author

Expert Systems for Predicting the Bioavailability of Sun Filters in Cosmetic Products, Software vs. Expert Formulator: The Benzophenone-3 Case.

Pharmaceutics·2022
Same author

Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?

Children (Basel, Switzerland)·2022
Same author

Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion.

Pharmaceutics·2021
Same author

Deodorants and antiperspirants: identification of new strategies and perspectives to prevent and control malodor and sweat of the body.

International journal of dermatology·2021

Related Experiment Video

Updated: May 5, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
09:04

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

7.4K

Tissue engineered human skin equivalents.

Zheng Zhang1, Bozena B Michniak-Kohn

  • 1New Jersey Center for Biomaterials, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA. michniak@biology.rutgers.edu.

Pharmaceutics
|December 5, 2013
PubMed
Summary

Human skin equivalents are advanced tissue-engineered models used for topical and transdermal delivery research. These models are crucial for skin permeation, toxicity, and pharmacology studies.

Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Tissue Engineering

Background:

  • Human skin acts as a vital barrier and a pathway for topical/transdermal delivery.
  • Advancements in tissue engineering have driven the development of human skin equivalents (HSEs).
  • HSEs have commercial applications as skin substitutes and in safety assessments.

Purpose of the Study:

  • To review and discuss the state-of-the-art in human skin equivalent development.
  • To highlight the applications of HSEs in various research areas.
  • To provide insights into the progress of tissue engineering for skin applications.

Main Methods:

  • Review of academic and commercial research in human skin equivalents.
  • Analysis of tissue engineering and regenerative medicine advancements.

More Related Videos

Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models
08:32

Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models

Published on: October 20, 2023

3.7K
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

19.1K

Related Experiment Videos

Last Updated: May 5, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
09:04

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

7.4K
Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models
08:32

Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models

Published on: October 20, 2023

3.7K
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

19.1K
  • Examination of HSE applications in permeation, toxicity, and pharmacological studies.

    • Main Results:

    • HSEs are established as reliable models for skin research.
    • Significant progress has been made in developing sophisticated HSEs over three decades.
    • HSEs are utilized for diverse applications including permeation, corrosivity, irritation, and toxicity testing.

    Conclusions:

    • Human skin equivalents represent a significant achievement in tissue engineering.
    • HSEs are versatile tools for both clinical and research purposes.
    • Continued development of HSEs will further advance skin science and drug delivery.